Yes, Cushing’s Disease compromises your horse’s immune system putting it at a greater risk of contracting infection. The reason is these horses have higher levels of circulating natural steroids which depress/suppress the immune system. Wounds and scrapes may not heal on their own and could require medications. It is also important to work with your vet to create an appropriate worming schedule, as horses with Cushing’s Disease will be less equipped to ward off parasites.